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KMID : 0376419830070010125
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Chonbuk University Medical Journal
1983 Volume.7 No. 1 p.125 ~ p.130
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Studies on the Glycosylation of the Hemoglobin of Diabetes Mellitus
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Abstract
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The concentration of HbAlc, non-enzymatic glycosylation product of major hemoglobin A has been reported to be an effective indicator of hyperglycemia since it reflects the integrated blood glucose level over period of weeks. The average percentage of HbA1c was 11.4±2.90 in diabetes mellitus, 5. 1 ± 1.40 in normal control and 6.5 ± 1.69 in other diseases group. The amount of HbA1c was significantly correlated with the fasting blood sugar value, showing the clinical significance of HbAlc test for Vie diagnosis of diabete3 mellitus whereas the level of HbA,c and the duration or complication of diabetes mellitus showed no notable correlation ip.
The rate of the formation of Schiff base of various mohosaccharides with hemoglobin was investigated and the results of which showed the presence of ribose in the hemolysates markedly enhanced the non-enzymatic glycosylation. Among the four monosaccharides tested, glucose showed least reactivity for the deleterious non-enzymatic glycosylation due in part to the high stability of its pyranose ring structure.
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KEYWORD
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